danio.mgh harvard.edu

Drummond Lab The zebrafish kidney Massachusetts General Hospital

We established the zebrafish kidney as a system to study kidney organogenesis, cell type differentiation, and to model human disease. Our work on ciliopathies using zebrafish genetics lead to the identification of novel genes required for both sensory and motile cilia function in human hereditary disease. This work identified links to broader networks controlling tubulin post-translational modifications, dynein arm assembly components, and regulation of cilia length by membrane protein delivery. We discover
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Drummond Lab The zebrafish kidney Massachusetts General Hospital

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We established the zebrafish kidney as a system to study kidney organogenesis, cell type differentiation, and to model human disease. Our work on ciliopathies using zebrafish genetics lead to the identification of novel genes required for both sensory and motile cilia function in human hereditary disease. This work identified links to broader networks controlling tubulin post-translational modifications, dynein arm assembly components, and regulation of cilia length by membrane protein delivery. We discover

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This site has the following in the site, "Our research focuses on kidney development and the differentiation of renal cell types." Our analyzers noticed that the web page also stated " The zebrafish offers many experimental advantages for studies of kidney development." The Website also stated " The zebrafish pronephros is a remarkably simple kidney, consisting of only two nephrons with glomeruli fused at the midline, pronephric tubules connecting directly to the glomeruli via a neck segment, and paired bilateral pronephric ducts which convey the blood filtrate outside the animal. Read current literature on the pronephros."

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